Neurological Biomarkers

The major aim of biomarker research in neurology has been to provide clinicians with biochemical and neuroimaging tools that enable accurate diagnosis before widespread neuronal death has occurred. Such biomarkers are a prerequisite for effective secondary prevention strategies, and may also facilitate therapeutics by (i) providing measures of desired biochemical effects of a compound in the preclinical drug discovery phase; (ii) allowing the specific inclusion of early cases that are very likely to develop the disease of interest; and (iii) identifying subgroups of patients according to biochemical patterns to individualize treatment. In addition, biomarker changes during disease progression and correlations between different biomarkers may provide clues on pathogenic mechanisms. Several studies have already been conducted, most of them using the Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers total and phosphorylated tau proteins that reflect the axonal component of the disease and the 42-amino acid fragment of amyloid β (Aβ42) that reflects plaque pathology in the brain to diagnose AD before onset of dementia.

 

  • Early identification of Neurological disorders
  • Monitoring of treatment efficiency & progression
  • High-performance plasma amyloid-β biomarkers in Alzheimer’s disease
  • Biomarkers for α-synuclein pathology associated with Parkinson’s disease (PD)
  • Biomarkers for dementia with Lewy bodies (DLB), and multiple system atrophy (MSA)

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Neurological Biomarkers Conference Speakers

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